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Development of vascular substitues for low flow peripheral vascular reconstructions
Mitáš, Petr ; Špaček, Miroslav (advisor) ; Štádler, Petr (referee) ; Rohn, Vilém (referee)
The development of vascular replacement for low flow rates is a topical issue. The model for developing the development of replacement properties, which are based on the idea of assuming the characteristics of the biological model - vena saphena and programming these properties into a model of constructed replacement is one of the possible directions of development. The presented replacement, which is the result of the work of the author's team, consists of three parts - a non-absorbable scaffold representing the media, and two absorbable collagen layers - pseudointima and pseudoadventice. Target parameters of the prosthesis were determined by test results of the basic physical testing method - uniaxial tensile test and inflation-extension test, as well as other procedures in human saphenous specimens. The key issue is the technology of producing the collagen layer of the prosthesis. However, other manufacturing processes can also have a significant impact on vascular prosthesis properties, such as collagen hardening, antithrombogenic treatment of the inner surface of the vascular replacement, and the use of a sterilization method. Furthermore, the author deals with the development of a new female component of the three- layer vascular prosthesis of the Czech carp, which is characterized by lower...
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Development of vascular substitues for low flow peripheral vascular reconstructions
Mitáš, Petr ; Špaček, Miroslav (advisor) ; Štádler, Petr (referee) ; Rohn, Vilém (referee)
The development of vascular replacement for low flow rates is a topical issue. The model for developing the development of replacement properties, which are based on the idea of assuming the characteristics of the biological model - vena saphena and programming these properties into a model of constructed replacement is one of the possible directions of development. The presented replacement, which is the result of the work of the author's team, consists of three parts - a non-absorbable scaffold representing the media, and two absorbable collagen layers - pseudointima and pseudoadventice. Target parameters of the prosthesis were determined by test results of the basic physical testing method - uniaxial tensile test and inflation-extension test, as well as other procedures in human saphenous specimens. The key issue is the technology of producing the collagen layer of the prosthesis. However, other manufacturing processes can also have a significant impact on vascular prosthesis properties, such as collagen hardening, antithrombogenic treatment of the inner surface of the vascular replacement, and the use of a sterilization method. Furthermore, the author deals with the development of a new female component of the three- layer vascular prosthesis of the Czech carp, which is characterized by lower...
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Water hammer experiment in artificial blood vessel
Hromádka, D. ; Horný, L. ; Žitný, R. ; Chlup, Hynek
This paper presents a water hammer experiment performed on an artificial blood vessel and the latex tube. Artificial blood vessel was manufactured from latex tubes and textile rubber bands. These bands were wound on outer surface of latex tube and they imitated reinforcing effect of collagen fibres. Mathematical model describes pulsation of pressure after instantaneous closing of valve at outlet of pipeline a part of which is a short elastic tested tube. It is shown that the observed pressure responses can be approximated by a simplified mathematical model assuming linear relationship between internal pressure and inflated volume.
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